Key result
A combination of thrombectomy, catheter-directed thrombolysis, and antithrombin concentrate successfully dissolved clots and restored blood flow in a patient with antithrombin deficiency and medical refractory deep vein thrombosis.
Why the study?
Does thrombectomy and catheter-directed thrombolysis combined with antithrombin concentrate improve clot dissolution in patients with antithrombin deficiency and medical refractory deep vein thrombosis?
Case Report (n=1)
No
Does thrombectomy and catheter-directed thrombolysis combined with antithrombin concentrate improve clot dissolution in patients with antithrombin deficiency and medical refractory deep vein thrombosis?
Thrombectomy and catheter-directed thrombolysis combined with antithrombin concentrate is an effective approach to treat medical refractory deep vein thrombosis in patients with antithrombin deficiency.
Answers are grounded in this paper and cite their sources.
Offers potential strategy for refractory DVT with antithrombin deficiency; hypothesis-generating and should not yet change practice.
A 22-year-old male was admitted to our hospital with deep vein thrombosis that was complicated by antithrombin deficiency. This deficiency was refractory to anticoagulation therapy. Although catheter-directed thrombolysis could not reperfuse the total occlusion in the left deep vein, a combination of thrombectomy, catheter-directed thrombolysis, and antithrombin concentrate treatment was able to dissolve the clots and ameliorate the blood flow into the left deep vein. Antithrombin concentrate administration would be effective in the treatment of antithrombin deficiency with medical refractory deep vein thrombosis.
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Maeba et al. (2016) conducted a case report in Antithrombin deficiency complicated by acute deep vein thrombosis refractory to anticoagulation (n=1). Thrombectomy and catheter-directed thrombolysis combined with antithrombin concentrate was evaluated on Dissolution of clots and amelioration of blood flow. A combination of thrombectomy, catheter-directed thrombolysis, and antithrombin concentrate successfully dissolved clots and restored blood flow in a patient with antithrombin deficiency and medical refractory deep vein thrombosis.
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