Key result
In rats, radioiodinated VLDL and chylomicron remnants are internalized and degraded by hepatocytes via receptor-mediated endocytosis, with no significant role for nonparenchymal cells.
Population
Rats (in vivo model)
Design
Preclinical
Follow-up
3 to 30 minutes
Authors
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Should not yet guide remnant-targeted therapies in humans; leaves open translation of hepatocyte-dominant clearance from rodent models.
This preclinical study demonstrates that triglyceride-rich lipoprotein remnants are processed by liver parenchymal cells via classical receptor-mediated endocytosis, similar to LDL.
Jones et al. (1984) studied this question. Radioiodinated plasma VLDL remnants and lymph chylomicron remnants was evaluated on Intracellular transport and catabolism pathway in hepatocytes and nonparenchymal cells. In rats, radioiodinated VLDL and chylomicron remnants are internalized and degraded by hepatocytes via receptor-mediated endocytosis, with no significant role for nonparenchymal cells.
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