Key result
An intact marginal bundle of microtubules is essential for the maintenance of platelet shape, but intact microtubules are not essential for ADP-induced platelet aggregation or clot retraction.
Intact microtubules are necessary for maintaining platelet shape but not for ADP-induced aggregation or clot retraction.
Animal platelet data suggest microtubule-independent aggregation; leaves open human translation and therapeutic targeting.
Human blood platelets were treated in vitro with various chemicals to test whether a chemical which affects microtubules (demecolcine) also affects platelet shape and platelet function (aggregation and contraction) and whether chemicals which affect platelet function (cyanide, monoidoacetate, cyanide plus monoiodoacetate, fluoride, Ouabain, N‐ethylmaleimide, Mersalyl, and cocaine) also affect platelet shape and platelet microtubules. It is concluded that an intact marginal bundle of microtubules is essential for the maintenance of platelet shape but intact microtubules are not essential for ADP‐induced platelet aggregation or for clot retraction.
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O. Behnke (1970) studied Human blood platelets (in vitro). Various chemicals (demecolcine, cyanide, monoiodoacetate, fluoride, Ouabain, N-ethylmaleimide, Mersalyl, cocaine) was evaluated on Platelet shape, platelet function (aggregation and contraction), and platelet microtubules. An intact marginal bundle of microtubules is essential for the maintenance of platelet shape, but intact microtubules are not essential for ADP-induced platelet aggregation or clot retraction.
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