Key result
Doxorubicin therapy in a 42-year-old woman with synovial sarcoma resulted in a severe hypersensitivity reaction including erythema, urticaria, and asthma despite antihistamine pretreatment.
Case Report (n=1)
Doxorubicin can cause severe hypersensitivity reactions including skin flares, urticaria, and asthma, which may not be fully prevented by antihistamine pretreatment.
May warrant vigilance for doxorubicin hypersensitivity despite antihistamines; single case leaves open optimal prevention strategies.
A 42-year-old woman with synovial sarcoma developed a skin flare during doxorubicin therapy. With a subsequent dose, erythema, urticaria, and asthma occurred, despite pretreatment with antihistamines. Skin flares occur in about three percent of patients receiving doxorubicin. Rarely, generalized urticaria, angioneurotic edema, or anaphylaxis occur. Local reactions may represent molecular extravasation through vessels, or histamine release from mast cells or basophils. Generalized reactions may involve alternative complement-activation pathways. Pretreatment with antihistamines or corticosteroids sometimes is helpful in preventing recurrences.
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Judy A. Collins (1984) conducted a case report in Synovial sarcoma (n=1). Doxorubicin was evaluated on Hypersensitivity reaction (skin flare, erythema, urticaria, asthma). Doxorubicin therapy in a 42-year-old woman with synovial sarcoma resulted in a severe hypersensitivity reaction including erythema, urticaria, and asthma despite antihistamine pretreatment.
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