Key result
Average blood volume remained 19% less than predicted in men 5 years after coronary artery bypass grafting, indicating a persisting disturbed regulation mechanism.
Why the study?
Does coronary artery bypass grafting normalize blood volume in men with stable angina pectoris 5 years post-surgery?
Observational (n=77)
Does coronary artery bypass grafting normalize blood volume in men with stable angina pectoris 5 years post-surgery?
Effect estimate: 19% less than predicted
Blood volume remains persistently reduced 5 years after successful CABG in men with stable angina, independent of symptomatic or physiological improvement.
Persistent post-CABG hypovolemia should not alter management; leaves open prognostic relevance and mechanisms for prospective study.
Patients with stable angina pectoris are reported to have a markedly reduced blood volume (BV). In the present study, average BV was still 19% less than that predicted in 77 men examined 5 years after coronary artery bypass grafting. Beneficial effects of the operation such as relieved angina, absence of medication, complete revascularization status at repeat angiography, and restored physical fitness were not found to be associated with a normalization of the BV. No significant correlation was found between BV and body weight, heart volume, exercise capacity, ejection fraction or left ventricular end-diastolic pressure. The reduced BV in patients with angina pectoris after successful revascularization and the absence of correlation with physiological variables indicate a persisting disturbed regulation mechanism.
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Ivert et al. (1989) conducted an observational in Stable angina pectoris post-CABG (n=77). Coronary artery bypass grafting vs. Predicted blood volume was evaluated on Blood volume (19% less than predicted). Average blood volume remained 19% less than predicted in men 5 years after coronary artery bypass grafting, indicating a persisting disturbed regulation mechanism.
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