Why the study?
Do saline extracts of atria from BIO 14.6 hamsters have reduced natriuretic and diuretic effects compared to normal hamsters?
Do saline extracts of atria from BIO 14.6 hamsters have reduced natriuretic and diuretic effects compared to normal hamsters?
The deficiency of atrial natriuretic factor in BIO 14.6 hamsters may be the humoral mediator responsible for their development of congestive heart failure and edema.
Answers are grounded in this paper and cite their sources.
May link atrial natriuretic factor deficiency to edema in this hamster model; leaves open relevance to human heart failure.
The hearts of 220-day-old hamsters of the BIO 14.6 strain are deficient in atrial natriuretic factor; saline extracts of atria produce one-third the natriuretic and diuretic effects of extracts of atria from age-matched normal hamsters. BIO 14.6 hamsters are known to develop congestive heart failure with edema when they are about 200 days old, and the venous congestion and edema are preventable by parabiosis with normal hamsters. The humoral mediator, the deficiency of which causes venous congestion and edema in BIO 14.6 hamsters, may be atrial natriuretic factor.
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Chimoskey et al. (1984) studied this question.
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