What is the clinical evidence from this study?

Study design: Observational. Population: Malignant hyperthermia (n=47). Intervention: Familial genetic background vs. Other families. Primary outcome: Strength of muscle contractures to halothane and caffeine challenges.

June 1, 1994Anesthesiology

Genetic Effects on the Variability of the Halothane and Caffeine Muscle Contracture Tests

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Key result

Familial genetic background significantly influenced in vitro muscle contractures to halothane and caffeine, with some families showing markedly higher contracture strengths than others.

Population

47 subjects from four families with a malignant hyperthermia-related death and with at least five clinically…

Comparison

In vitro muscle contracture tests with… vs Comparison among the four different families

Design

Cross-sectional

Authors

AUAlbert UrwylerUniversity of Basel KCK. CensierUniversity of Basel MKMark KaufmannUniversity of Basel

Discussion

Member takes

Implication

Familial IVCT variability may affect MH diagnostic thresholds; leaves open genotype-specific reference standardization.

Study Design

Type

Observational (n=47)

Structured PICO

Population

47 subjects from four families with a history of malignant hyperthermia-related death and multiple susceptible individuals.

Exposure

In vitro muscle contracture tests with halothane, caffeine, or both

Comparator

Comparison among the four different families

Outcome

Strength of muscle contractures to challenges of halothane, caffeine, or both and the effect of these two drugs on twitch potentiation in response to supramaximal electrical stimulationsurrogate

In vitro muscle contracture tests show significant variability among different families with malignant hyperthermia, providing evidence for genetic influences on the test procedure.

Limitations

It is not known if the observed differences are caused by heterogeneity of the MH gene mutation(s) or by other genetic factors that might modify muscle contractures in vitro.

Cite This Study

Urwyler et al. (1994) conducted an observational in Malignant hyperthermia (n=47). Familial genetic background vs. Other families was evaluated on Strength of muscle contractures to halothane and caffeine challenges. Familial genetic background significantly influenced in vitro muscle contractures to halothane and caffeine, with some families showing markedly higher contracture strengths than others.

synapsesocial.com/papers/6a92ab7964e69d4ef3467396 https://doi.org/10.1097/00000542-199406000-00016

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June 1, 1994Anesthesiology

Genetic Effects on the Variability of the Halothane and Caffeine Muscle Contracture Tests

View Full Paper

Ask AI

Bookmark

Key result

Familial genetic background significantly influenced in vitro muscle contractures to halothane and caffeine, with some families showing markedly higher contracture strengths than others.

Population

47 subjects from four families with a malignant hyperthermia-related death and with at least five clinically…

Comparison

In vitro muscle contracture tests with… vs Comparison among the four different families

Design

Cross-sectional

Authors

AUAlbert UrwylerUniversity of Basel KCK. CensierUniversity of Basel MKMark KaufmannUniversity of Basel

Discussion

Member takes

Implication

Familial IVCT variability may affect MH diagnostic thresholds; leaves open genotype-specific reference standardization.

Study Design

Type

Observational (n=47)

Structured PICO

Population

47 subjects from four families with a history of malignant hyperthermia-related death and multiple susceptible individuals.

Exposure

In vitro muscle contracture tests with halothane, caffeine, or both

Comparator

Comparison among the four different families

Outcome

Strength of muscle contractures to challenges of halothane, caffeine, or both and the effect of these two drugs on twitch potentiation in response to supramaximal electrical stimulationsurrogate

In vitro muscle contracture tests show significant variability among different families with malignant hyperthermia, providing evidence for genetic influences on the test procedure.

Limitations

It is not known if the observed differences are caused by heterogeneity of the MH gene mutation(s) or by other genetic factors that might modify muscle contractures in vitro.

Cite This Study

synapsesocial.com/papers/6a92ab7964e69d4ef3467396 https://doi.org/10.1097/00000542-199406000-00016

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