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July 1, 1987Acta Anaesthesiologica Scandinavica

In vitro diagnosis of susceptibility to malignant hyperthermia: comparison between dynamic and static halothane and caffeine tests

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Why the study?

Do dynamic halothane and caffeine tests improve the diagnosis of malignant hyperthermia susceptibility compared to static tests?

Population

105 patients and 20 normal controls

Comparison

Dynamic halothane and caffeine tests vs Static halothane and caffeine tests

Design

Other

Authors

HØHelle ØrdingUniversity of Southern DenmarkLSLene Theil SkovgaardUniversity of Copenhagen

Discussion

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Implication

Dynamic halothane and caffeine tests are not superior to static tests for the in vitro diagnosis of malignant hyperthermia susceptibility.

Structured PICO

Do dynamic halothane and caffeine tests improve the diagnosis of malignant hyperthermia susceptibility compared to static tests?

P
Population
105 patients and 20 normal controls
I
Intervention
Dynamic halothane and caffeine tests (muscle bundle length cyclically changed)
C
Comparator
Static halothane and caffeine tests (constant muscle bundle length)
O
Outcome
Threshold concentrations eliciting contractures and diagnostic resultssurrogate

Dynamic halothane and caffeine tests are not superior to static tests for the in vitro diagnosis of malignant hyperthermia susceptibility.

Cite This Study

Ørding et al. (1987) studied this question.

synapsesocial.com/papers/6a703dfce36a167817e1fee6https://doi.org/10.1111/j.1399-6576.1987.tb02603.x
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Incidence of Malignant Hyperthermia in Denmark1985 · 182 citations