Key result
Consecutive exposures to carbamylcholine did not show signs of desensitization in the automaticity of the guinea pig sinus node or transmembrane potentials of transitional fibers.
Consecutive exposures to carbamylcholine do not cause desensitization in the guinea pig sinus node.
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Sustained guinea pig sinus node responsiveness without desensitization; leaves open translation to human vagal modulation.
Carpentier et al. (1984) studied this question. Carbamylcholine (CBL) was evaluated on Sinus node automaticity and transmembrane potentials of transitional fibers. Consecutive exposures to carbamylcholine did not show signs of desensitization in the automaticity of the guinea pig sinus node or transmembrane potentials of transitional fibers.
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