Key result
Failing heart muscles demonstrated altered maximum diastolic potential changes during cooling/rewarming and rapid stimulation compared to normal muscles, suggesting an altered electrogenic Na-K pump.
Population
16 papillary muscles (6 from control animals and 10 from banded animals with failing hearts)
Comparison
Cooling and subsequent rewarming to 37 degrees… vs Papillary muscles from normal control animals
Design
Preclinical
Authors
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May implicate Na-K pump dysfunction in failing myocardium; leaves open translation to human arrhythmias or therapies.
Altered resting potential changes in failing heart muscle during cooling/rewarming and rapid stimulation suggest dysfunction of the electrogenic Na-K pump.
Houser et al. (1981) studied Heart failure (n=16). Failing heart muscle vs. Normal heart muscle was evaluated on Changes in maximum diastolic potential (--Emax) on rewarming and rapid stimulation. Failing heart muscles demonstrated altered maximum diastolic potential changes during cooling/rewarming and rapid stimulation compared to normal muscles, suggesting an altered electrogenic Na-K pump.
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