Double Blind, Randomised Controlled Study for Comparative Evaluation of Equal Volume of Two Different Doses of Ropivacaine Hydrochloride (0.75% and 0.5%) in Spinal Anaesthesia in Lower Limb Orthopaedic Surgery Regarding the Onset and Duration of Sensory and Motor Blockade

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Lower limb orthopaedic surgery (n=80). Intervention: Ropivacaine Hydrochloride vs. 15 mg (3 mL) of 0.5% isobaric Ropivacaine Hydrochloride. Primary outcome: Total duration of sensory blockade (time to regression to S1 in minutes) (p=<0.001).

Shafaqat Rashid; Suhail Vakil; Roshani Deshmukh; Zameer Ali; Mehreen Rashid; Nikhil Chamankar; Swarn Gulati

doi:10.14260/jemds/2017/934

July 20, 2017Journal of Evolution of Medical and Dental SciencesOpen Access

Double Blind, Randomised Controlled Study for Comparative Evaluation of Equal Volume of Two Different Doses of Ropivacaine Hydrochloride (0.75% and 0.5%) in Spinal Anaesthesia in Lower Limb Orthopaedic Surgery Regarding the Onset and Duration of Sensory and Motor Blockade

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Key result

Intrathecal ropivacaine 0.75% significantly prolonged the total duration of sensory blockade (193.5 vs 146.0 minutes) and motor blockade (190.5 vs 137.5 minutes) compared to ropivacaine 0.5%.

Why the study?

Does 0.75% ropivacaine improve the onset and duration of sensory and motor blockade compared to 0.5% ropivacaine in patients undergoing lower limb orthopaedic surgery under spinal anaesthesia?

Study Design

Type

RCT (n=80)

Blinding

Double-blind

Randomization

Sealed envelope method with computer-generated numbers

Multicenter

No

Structured PICO

Does 0.75% ropivacaine improve the onset and duration of sensory and motor blockade compared to 0.5% ropivacaine in patients undergoing lower limb orthopaedic surgery under spinal anaesthesia?

P

Population

80 adults aged 20-65 years with ASA physical status I or II undergoing lower limb orthopaedic surgery were randomized to receive spinal anaesthesia with either 0.75% or 0.5% ropivacaine.

I

Intervention

Ropivacaine hydrochloride 0.75% isobaric, 22.5 mg (3 mL) administered intrathecally.

C

Comparator

Ropivacaine hydrochloride 0.5% isobaric, 15 mg (3 mL) administered intrathecally.

O

Outcome

Onset and duration of sensory and motor blockade.

Main Result

Absolute Event Rate: 193.5% vs 146%

p-value: p=<0.001

Intrathecal ropivacaine 0.75% provides a significantly longer duration of sensory and motor blockade compared to 0.5% ropivacaine, making it highly suitable for lower limb orthopaedic surgeries requiring intense blockade.

Implication

Supports 0.75% ropivacaine for prolonged lower limb orthopedic procedures; extends RCT dose-response data for intrathecal ropivacaine.

Abstract

Central neuraxial blockade is a major regional anaesthesia technique with a long history of effective use for a variety of surgical procedures and pain relief. Ropivacaine is an amino-amide local anaesthetic drug, which was first synthesised in 1957 and was introduced into clinical practice in 1996. As there are limited studies on effect of ropivacaine in spinal anaesthesia, we conducted a dose comparison study of ropivacaine in our institute to know the clinical efficacy and safety with regard to better patient profile management.

Discussion

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Cite This Study

Rashid et al. (2017) conducted an RCT in Lower limb orthopaedic surgery (n=80). Ropivacaine Hydrochloride vs. 15 mg (3 mL) of 0.5% isobaric Ropivacaine Hydrochloride was evaluated on Total duration of sensory blockade (time to regression to S1 in minutes) (p=<0.001). Intrathecal ropivacaine 0.75% significantly prolonged the total duration of sensory blockade (193.5 vs 146.0 minutes) and motor blockade (190.5 vs 137.5 minutes) compared to ropivacaine 0.5%.

synapsesocial.com/papers/6a92af42eb36ee4226182f46 https://doi.org/10.14260/jemds/2017/934

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Double Blind, Randomised Controlled Study for Comparative Evaluation of Equal Volume of Two Different Doses of Ropivacaine Hydrochloride (0.75% and 0.5%) in Spinal Anaesthesia in Lower Limb Orthopaedic Surgery Regarding the Onset and Duration of Sensory and Motor Blockade

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

Double Blind, Randomised Controlled Study for Comparative Evaluation of Equal Volume of Two Different Doses of Ropivacaine Hydrochloride (0.75% and 0.5%) in Spinal Anaesthesia in Lower Limb Orthopaedic Surgery Regarding the Onset and Duration of Sensory and Motor Blockade

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

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