Key result
Both 0.75% and 0.5% doses of intrathecal ropivacaine provided a high degree of cardiovascular stability with comparable haemodynamic profiles and no statistically significant differences in heart rate or blood pressure (p > 0.05).
Why the study?
Does 0.75% ropivacaine compared to 0.5% ropivacaine improve haemodynamic stability or reduce complications in patients undergoing lower limb orthopaedic surgeries under spinal anaesthesia?
Population
80 patients of American Society of Anaesthesiologists physical status I and II, age 20-65 years of either…
Comparison
22.5 mg of 0.75% isobaric ropivacaine… vs 15 mg of 0.5% isobaric ropivacaine hydrochloride…
Design
RCT, Randomised by sealed envelope method, Double-blind manner; investigators…
Follow-up
Intraoperative period and next 24 hours after the operation
Authors
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Either dose supports stable spinal anaesthesia; confirms haemodynamic equivalence of 0.5% and 0.75% ropivacaine in lower limb surgery.
RCT (n=80)
Double-blind
Sealed envelope method with computer-generated numbers
No
Does 0.75% ropivacaine compared to 0.5% ropivacaine improve haemodynamic stability or reduce complications in patients undergoing lower limb orthopaedic surgeries under spinal anaesthesia?
p-value: p=>0.05
Both 0.75% and 0.5% isobaric ropivacaine provide comparable haemodynamic stability and low complication rates when used for spinal anaesthesia in lower limb orthopaedic surgeries.
Rashid et al. (2017) conducted an RCT in Lower limb orthopaedic surgeries (n=80). Ropivacaine Hydrochloride 0.75% vs. Ropivacaine Hydrochloride 0.5% (15 mg, 3 mL) was evaluated on Haemodynamic changes (pulse rate, systolic and diastolic blood pressure, respiratory rate, oxygen saturation) (p=>0.05). Both 0.75% and 0.5% doses of intrathecal ropivacaine provided a high degree of cardiovascular stability with comparable haemodynamic profiles and no statistically significant differences in heart rate or blood pressure (p > 0.05).
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