Key result
Epidural anaesthesia with 0.5% ropivacaine provided comparable sensory and motor blockade to 0.5% bupivacaine, with no significant difference in motor blockade duration (p>0.05).
Why the study?
Does 0.5% ropivacaine provide comparable epidural anaesthesia to 0.5% bupivacaine in patients undergoing lower abdominal and lower extremity surgery?
RCT (n=50)
randomized
Does 0.5% ropivacaine provide comparable epidural anaesthesia to 0.5% bupivacaine in patients undergoing lower abdominal and lower extremity surgery?
p-value: p=>0.05
Ropivacaine 0.5% provides comparable sensory and motor blockade to bupivacaine 0.5% for epidural anesthesia in lower abdominal and extremity surgeries.
Supports ropivacaine as an alternative to bupivacaine for epidural anesthesia; confirms comparable blockade in lower abdominal and extremity surgery.
BACKGROUND: Ropivacaine, a derivative of mepivacaine like its older counterpart Bupivacaine, has recently been introduced in Indian pharmacopeia. Ropivacaine is an amide local anaesthetic but less cardiotoxic than bupivacaine.OBJECTIVE: To compare the clinical effectiveness of ropivacaine versus bupivacaine in patients undergoing lower extremity and lower abdominal surgeriesMETHODS: 50 patients were randomized to receive 20ml of 0.5% ropivacaine or 0.5% bupivacaine through epidural catheter. Sensory (pinprick) and motor (bromage) measurements were made while the block was in effect, haemodynamic changes; use of additional analgesics and sedatives was noted.RESULTS: The quality and extent of sensory and motor blockade between the two groups was comparable, although bupivacaine was found to be slightly longer acting. Both had similar motor blocking characteristics, with the exception that bupivacaine had a blockade of slightly longer duration but statistically not significant(p>0.05).CONCLUSION: Ropivacaine being lesser cardio toxic is the preferred agent for clinical epidural anaesthesia. JMS 2011;14(1):15-18
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Ommid et al. (2011) conducted an RCT in Lower abdominal and lower extremity surgery (n=50). Ropivacaine vs. 20ml of 0.5% bupivacaine was evaluated on Quality and extent of sensory and motor blockade (p=>0.05). Epidural anaesthesia with 0.5% ropivacaine provided comparable sensory and motor blockade to 0.5% bupivacaine, with no significant difference in motor blockade duration (p>0.05).
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