Key result
Epidural 1% ropivacaine (20 mL) provided similar onset, extent, and duration of sensory and motor block compared to 0.75% bupivacaine in 44 patients undergoing gynecologic surgery.
Why the study?
Does 1% ropivacaine provide similar anesthetic efficacy and safety compared to 0.75% bupivacaine in patients undergoing lower abdominal gynecologic surgery?
RCT (n=44)
Double-blind
Does 1% ropivacaine provide similar anesthetic efficacy and safety compared to 0.75% bupivacaine in patients undergoing lower abdominal gynecologic surgery?
1% ropivacaine offers equivalent epidural anesthesia to 0.75% bupivacaine; confirms its role as a safe alternative in gynecologic surgery.
A randomized double-blind study was performed to compare ropivacaine and bupivacaine in epidural anesthesia for intraperitoneal surgery. Forty-four patients undergoing epidural anesthesia for intraperitoneal lower abdominal gynecologic surgery received 20 mL of either 1% ropivacaine or 0.75% bupivacaine via an epidural catheter. There was no difference between the two drugs in the onset, extent, and duration of sensory and motor block. Satisfactory conditions for surgery were produced in the same number of patients in each group. The cardiovascular changes and the overall incidence of adverse reactions were similar for both drugs. It is concluded that ropivacaine is an effective and safe alternative to bupivacaine when used in epidural anesthesia for lower abdominal, intraperitoneal surgery.
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Wood et al. (1993) conducted an RCT in Intraperitoneal lower abdominal gynecologic surgery (n=44). 1% ropivacaine vs. 0.75% bupivacaine was evaluated on Onset, extent, and duration of sensory and motor block. Epidural 1% ropivacaine (20 mL) provided similar onset, extent, and duration of sensory and motor block compared to 0.75% bupivacaine in 44 patients undergoing gynecologic surgery.
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