Key result
High cumulative doses of metronidazole (greater than 40 g) are associated with seizures, indicating that cumulative dose rather than serum level drives this complication.
High cumulative doses of metronidazole (>40 g) are associated with convulsions, highlighting the importance of cumulative dose over serum levels in this complication.
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May prompt cumulative metronidazole dose monitoring; case report leaves open prospective validation.
Metronidazole in high cumulative doses has been associated with convulsions. A case is presented in which this relationship is clear. In all reported cases of metronidazole-associated seizures, the cumulative dose of metronidazole has been high (greater than 40 g). The cumulative dose rather than the serum level is important in the pathogenesis of this complication.
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Thomas J. Halloran (1982) studied this question. High cumulative doses of metronidazole (greater than 40 g) are associated with seizures, indicating that cumulative dose rather than serum level drives this complication.
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