Key result
SIV encephalitis in rhesus monkeys was associated with syncytial cells in other tissues, persistent antigenemia, decreased CD4+CD29+ lymphocytes, and shortened survival.
Observational (n=204)
Should not inform HIV care; leaves open confirmation of SIV encephalitis associations in primate models.
Necropsy records from 204 SIV-infected rhesus monkeys that had been inoculated with various strains of SIV and had died of SIV-related disease were reviewed. The relationship of SIV encephalitis with other parameters was evaluated. Encephalitis was associated with the presence of syncytial cells in other tissues, with persistent or early recurrent antigenemia, with a selective decrease in CD4+CD29+ blood lymphocytes, and with a shortened time of survival. Monkeys whose lymphocytes produced high levels of virus in culture also had a higher incidence of encephalitis. SIV was more frequently isolated from the brains of animals with encephalitis. No other clear associations were detected.
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Baskin et al. (1992) conducted an observational in SIV infection (n=204). SIV encephalitis vs. Absence of SIV encephalitis was evaluated on Correlates of SIV encephalitis. SIV encephalitis in rhesus monkeys was associated with syncytial cells in other tissues, persistent antigenemia, decreased CD4+CD29+ lymphocytes, and shortened survival.
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