Key result
Intravenous injection of poliomyelitis virus resulted in detectable virus in the cerebrospinal fluid starting at 72 hours and persisting until the onset of paralysis at 19 days.
Why the study?
Does intravenous injection of poliomyelitis virus lead to its penetration into the cerebrospinal fluid?
Population
Animal model (implied by inoculation test and intravenous injection)
Design
Preclinical
Follow-up
Up to 19 days
Authors
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Suggests choroid plexus penetration in experimental poliomyelitis; leaves open human pathogenesis and therapeutic relevance.
Does intravenous injection of poliomyelitis virus lead to its penetration into the cerebrospinal fluid?
The poliomyelitis virus can penetrate the choroid plexus barrier from the blood into the cerebrospinal fluid over time, which is important in the pathogenesis of epidemic poliomyelitis.
Flexner et al. (1914) studied Poliomyelitis. Intravenous injection of poliomyelitis virus was evaluated on Detection of virus in cerebrospinal fluid. Intravenous injection of poliomyelitis virus resulted in detectable virus in the cerebrospinal fluid starting at 72 hours and persisting until the onset of paralysis at 19 days.
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