What question did this study set out to answer?

To evaluate the incidence and characteristics of detectable viremia in young infants following immunization with the live attenuated Sabin oral poliovirus vaccine.

January 1, 1964American Journal of Epidemiology

Viremia in Infants Vaccinated With Oral Poliovirus Vaccine (Sabin)1*

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Key result

Oral poliovirus vaccine (Sabin) is associated with viremia in vaccinated infants.

Authors

DHDorothy M. HorstmannUnited States Army Medical Command EOEdward M. OptonMorrison Tech RKR. M. M. KlempererAston University

Discussion

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Implication

Warrants vigilance for viremia in OPV-vaccinated infants; leaves open questions on transmissibility and safety.

Key Points

To evaluate the incidence and characteristics of detectable viremia in young infants following immunization with the live attenuated Sabin oral poliovirus vaccine.
Administered oral poliovirus vaccine (Sabin strains) to a cohort of infant participants.
Collected sequential blood samples post-administration to assay for circulating poliovirus.
Detected transient poliovirus viremia in vaccinated infants following oral vaccine administration.
Observed systemic viral dissemination patterns characteristic of primary replication with attenuated Sabin strains.

Cite This Study

Horstmann et al. (1964) studied this question. Oral poliovirus vaccine (Sabin) is associated with viremia in vaccinated infants.

synapsesocial.com/papers/6a92b1f829f7ca37161f70da https://doi.org/10.1093/oxfordjournals.aje.a120363

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Viremia in Infants Vaccinated With Oral Poliovirus Vaccine (Sabin)1*

Discussion

Member takes

Implication

Key Points

Cite This Study

Viremia in Infants Vaccinated With Oral Poliovirus Vaccine (Sabin)1*

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider