Why the study?
Does intercurrent enterovirus infection inhibit vaccine virus take or antibody response to oral polio vaccine in children in the tropics?
Population
Infants and children in the tropics who were without antibodies to one, two or three serotypes of poliovirus
Comparison
Oral polio vaccine (OPV) vs Children without intercurrent enterovirus…
Design
Cohort
Authors
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Enterovirus co-infection does not explain reduced OPV immunogenicity in tropics; leaves open other host or environmental factors for prospective study.
Does intercurrent enterovirus infection inhibit vaccine virus take or antibody response to oral polio vaccine in children in the tropics?
Intercurrent enterovirus infections do not explain the lower rates of oral polio vaccine take and seroconversion observed in children in the tropics compared to temperate climates.
John et al. (1975) studied this question.
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