Why the study?
Does the presence of nonpolio enteroviruses and bacterial gut microbiota affect OPV seroconversion in Indian infants?
Population
704 Indian infants (aged 6-11 months)
Design
Cohort
Authors
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Recent NPEV may impair OPV immunogenicity in infants; leaves open whether microbiota interventions could enhance responses in LMICs.
Does the presence of nonpolio enteroviruses and bacterial gut microbiota affect OPV seroconversion in Indian infants?
Recent nonpolio enterovirus infections significantly reduce the serological response to oral poliovirus vaccine in infants, whereas bacterial microbiota has less impact.
Praharaj et al. (2018) studied this question.
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