Key result
Enterovirus quantity at the time of vaccination was associated with failure to seroconvert (OR 0.78; 95% CI 0.64-0.96; P=0.022) and breakthrough rotavirus diarrhea (OR 1.34; 95% CI 1.05-1.71; P=0.020).
Why the study?
Does concurrent enteropathogen infection reduce the immunogenicity and efficacy of oral polio and rotavirus vaccines in infants?
Cohort
Does concurrent enteropathogen infection reduce the immunogenicity and efficacy of oral polio and rotavirus vaccines in infants?
Odds Ratio: 0.78 (95% CI 0.64–0.96)
p-value: p=0.022
Enterovirus carriage at the time of vaccination is associated with reduced immunogenicity and protection of oral polio and rotavirus vaccines in infants.
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Enterovirus carriage was associated with poorer oral vaccine responses in infants; hypothesis-generating for timing adjustments before practice change.
Taniuchi et al. (2016) conducted a cohort in Enteric infections and vaccine performance. Enterovirus carriage vs. Lower quantity or absence of enterovirus was evaluated on Failure to seroconvert (OR 0.78, 95% CI 0.64-0.96, p=0.022). Enterovirus quantity at the time of vaccination was associated with failure to seroconvert (OR 0.78; 95% CI 0.64-0.96; P=0.022) and breakthrough rotavirus diarrhea (OR 1.34; 95% CI 1.05-1.71; P=0.020).
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