Key result
Nonpolio enterovirus detection at the time of vaccination was significantly higher in infants who did not respond to the oral poliovirus vaccine compared to responders (44% vs 29%; P<0.001).
Why the study?
Does the presence of nonpolio enteroviruses reduce OPV seroconversion in infants?
Does the presence of nonpolio enteroviruses reduce OPV seroconversion in infants?
Absolute Event Rate: 44% vs 29%
p-value: p=<.001
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The presence of nonpolio enteroviruses at the time of oral poliovirus vaccination is associated with reduced vaccine seroconversion in infants, highlighting the impact of the human virome on oral vaccine efficacy.
Ramani et al. (2018) conducted an editorial in Oral poliovirus vaccine (OPV) immunogenicity (n=704). OPV nonresponse vs. OPV response was evaluated on Detection of nonpolio enteroviruses at the time of vaccination (p=<.001). Nonpolio enterovirus detection at the time of vaccination was significantly higher in infants who did not respond to the oral poliovirus vaccine compared to responders (44% vs 29%; P<0.001).
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