Why the study?
Does the time since last oral poliovirus vaccination affect the rate of vaccine poliovirus excretion after a challenge dose in children?
Population
47,574 children with acute flaccid paralysis reported during 2005-2009 in India
Comparison
Oral poliovirus vaccine challenge dose vs Recent exposure to immunization activity
Design
Cohort
Follow-up
4-28 days after challenge dose
Authors
Loading...
Longer intervals since last OPV were associated with higher excretion after challenge; leaves open optimal boosting intervals to sustain mucosal immunity.
Does the time since last oral poliovirus vaccination affect the rate of vaccine poliovirus excretion after a challenge dose in children?
Intestinal mucosal immunity from oral poliovirus vaccine wanes significantly within a year of vaccination, highlighting the need for ongoing immunization in endemic areas.
Grassly et al. (2012) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: