Key result
Administration of three doses of oral polio vaccine achieved 100% seroconversion in winter, but lower rates in summer (e.g., 81.8% to 96.4% for type 3), especially in lower socio-economic groups and those excreting non-polio enteroviruses.
Why the study?
Do season of administration, socio-economic status, and presence of non-poliomyelitis viruses influence sero-conversion rates after oral polio vaccination in infants in a subtropical area?
Population
226 infants about 2 months of age living under normal home conditions and registered at six well-baby…
Comparison
Trivalent live oral poliovirus vaccine, two… vs No placebo control; comparisons were made…
Design
Cohort
Follow-up
2 months after the third dose
Authors
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Season and co-infections may lower OPV seroconversion in subtropical infants; leaves open optimized timing for low-SES groups.
Cohort (n=226)
Yes
Do season of administration, socio-economic status, and presence of non-poliomyelitis viruses influence sero-conversion rates after oral polio vaccination in infants in a subtropical area?
Three doses of trivalent oral polio vaccine provide excellent sero-conversion in subtropical climates, though rates are slightly lower in summer, in lower socio-economic groups, and in children excreting other enteroviruses.
Swartz et al. (1972) conducted a cohort in Poliomyelitis immunization (n=226). Trivalent live oral poliovirus vaccine vs. Summer administration vs Winter administration was evaluated on Sero-conversion rate after three doses of vaccine. Administration of three doses of oral polio vaccine achieved 100% seroconversion in winter, but lower rates in summer (e.g., 81.8% to 96.4% for type 3), especially in lower socio-economic groups and those excreting non-polio enteroviruses.
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