Population
Rat kidney medullary thick ascending limb (mTAL) cells
Comparison
Acute application of TNF (10 nM) vs Baseline/control (no TNF)
Design
Preclinical
Authors
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TNF effects on rat medullary K+ channels are hypothesis-generating; leaves open translation to human tubular function or disease.
TNF acutely stimulates the 70-pS K+ channel via stimulation of protein tyrosine phosphatase in the rat kidney medullary thick ascending limb.
Wei et al. (2003) studied this question.
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