Key result
Among 15 patients with HIV-associated pulmonary artery hypertension, active lymphocytic myocarditis was present in 12 (80%) and viral genomes were detected in 6 (40%).
Observational (n=15)
Inflammation and infection of the myocardium and intramural vessels are frequently detectable in patients with HIV-associated PAH and right ventricular dysfunction.
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Myocarditis may contribute to RV dysfunction in HIV-PAH; hypothesis-generating and should not yet change practice.
Frustaci et al. (2014) conducted an observational in HIV-associated pulmonary artery hypertension (n=15). HIV-associated pulmonary artery hypertension was evaluated on Myocardial histology and viral assessment. Among 15 patients with HIV-associated pulmonary artery hypertension, active lymphocytic myocarditis was present in 12 (80%) and viral genomes were detected in 6 (40%).
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