The piperidine alkaloid (–)‐allosedamine (1) has been synthesized, in 21% overall yield, in nine steps starting from the formyl‐ester 4. The synthesis features the reaction cascade 7 → 3 → 2, involving asymmetric electrophilic enolate hydroxyamination, hydroxylamine/aldehyde condensation, and nitrone/styrene cycloaddition, as well as the reductive N/O cleavage‐decyanation 12 → 1.
No takes yet. Share an insight, caveat, or question.
Oppolzer et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: