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The authors note observations of enhanced skin and esophageal radiation reactions in small-cell lung cancer patients treated with adriamycin-based chemotherapy and concomitant radiation.
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Highlights the potential for enhanced radiation toxicity (skin and esophageal) when adriamycin is combined with radiation therapy in lung cancer.
Comments and Correction1 February 1977Adriamycin and Radiation ReactionROBERT T. EAGAN, M.D., ROBERT E. LEE, M.D., DAVID T. CARR, M.D.ROBERT T. EAGAN, M.D.Search for more papers by this author, ROBERT E. LEE, M.D.Search for more papers by this author, DAVID T. CARR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-2-243 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the report by Greco and associates (1) on the enhanced skin and esophageal radiation reaction in small-cell lung cancer patients being treated with a three-drug combination chemotherapy program, including adriamycin (doxorubicin) at a dose of 40 mg/m2 followed by super voltage radiation. We are also aware of the reports by Donaldson, Glick, and Wilbur (2) and Cassady and associates (3). In light of the earlier reports, we have been closely observing our patients for similar reactions.Our approach to therapy has been an adriamycin-based combination chemotherapy regimen administered concomitantly with radiation therapy. The...References1. GRECOBRERETONKENT FHH: Adriamycin and enhanced radiation reaction in normal esophagus and skin. Ann Intern Med 85:294-298, 1976 LinkGoogle Scholar2. DONALDSONGLICKWILBUR SJJ: Adriamycin activating a recall phenomenon after radiation therapy. Ann Intern Med 81:407-408, 1974 LinkGoogle Scholar3. CASSADYRICHTERPIRO JMA: Radiation-adriamycin interactions: preliminary clinical observations. Cancer 26:946-949, 1975 CrossrefGoogle Scholar1. JOHNSON R: Combined radiotherapy and chemotherapy. Cancer 37 (suppl): 1214, 1976 CrossrefGoogle Scholar2. PHILIPSFU TK: Quantification of combined radiation therapy and chemotherapy effects on critical normal tissues. Cancer 37 (suppl): 1186-1200, 1976 CrossrefMedlineGoogle Scholar3. RUDOLPHSTEINPATILLO RRR: Skin ulcers due to Adriamycin. Cancer 38:1087-1094, 1976 CrossrefMedlineGoogle Scholar4. CASSADYRICHTERPIRO JMA: Radiation-Adriamycin interactions: preliminary clinical observations. Cancer 36:946-949, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT T. EAGAN, M.D.; ROBERT E. LEE, M.D.; DAVID T. CARR, M.D.Affiliations: Comprehensive Cancer Center Mayo Clinic Rochester, MN 55901 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTumoren der Atmungsorgane (Trachea, Bronchien, Lunge)Small-Cell Carcinoma of the Lung: Therapeutic ManagementRAYMOND B. WEISS, M.D., F.A.C.P. 1 February 1977Volume 86, Issue 2Page: 243-244KeywordsCombination chemotherapyLung and intrathoracic tumorsRadiation therapy ePublished: 1 December 2008 Issue Published: 1 February 1977 PDF downloadLoading ...
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Robert T. Eagan (1977) conducted a letter in Small-cell lung cancer. Adriamycin-based combination chemotherapy and radiation therapy was evaluated on Enhanced skin and esophageal radiation reaction. The authors note observations of enhanced skin and esophageal radiation reactions in small-cell lung cancer patients treated with adriamycin-based chemotherapy and concomitant radiation.
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