Key result
Combination chemotherapy, particularly adriamycin, potentiated the effect of radiotherapy, causing esophagitis in 80% and dermatitis in 50% of 10 patients with small cell lung carcinoma.
Why the study?
Does combination chemotherapy with adriamycin potentiate the effect of radiotherapy on normal esophagus and skin in patients with small cell carcinoma of the lung?
Population
10 patients with small cell carcinoma of the lung
Design
Case_series
Authors
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The combination of adriamycin-based chemotherapy and radiotherapy significantly increases the risk of severe esophageal and skin toxicity.
Observational (n=10)
Does combination chemotherapy with adriamycin potentiate the effect of radiotherapy on normal esophagus and skin in patients with small cell carcinoma of the lung?
The combination of adriamycin-based chemotherapy and radiotherapy significantly increases the risk of severe esophageal and skin toxicity.
F. Anthony Greco (1976) conducted an observational in Small cell carcinoma of the lung (n=10). Radiotherapy and combination chemotherapy (cyclophosphamide, vincristine, and adriamycin) was evaluated on Esophagitis. Combination chemotherapy, particularly adriamycin, potentiated the effect of radiotherapy, causing esophagitis in 80% and dermatitis in 50% of 10 patients with small cell lung carcinoma.
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