Population
Anesthetized rats, isolated rat anococcygeal muscle and right atrium, and human umbilical artery and vein…
Comparison
l-ephedrine and d-pseudoephedrine vs 6-hydroxydopamine (6-OHDA) pretreatment
Design
Preclinical
Authors
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Suggests indirect sympathomimetic action may preserve uteroplacental flow; hypothesis-generating and requires human confirmation before practice change.
The pressor response of l-ephedrine in vivo is entirely attributable to indirect norepinephrine release from sympathetic nerves, explaining its preservation of uteroplacental blood flow.
Kobayashi et al. (2003) studied this question.
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