Key result
Ephedrine and phenylephrine administered for blood pressure correction during elective cesarean section produced no significant differences in maternal or fetal atrial natriuretic peptide levels.
Why the study?
Does ephedrine compared to phenylephrine differentially affect maternal and fetal atrial natriuretic peptide levels during elective cesarean section?
Population
30 pregnant women undergoing elective cesarean section under spinal anesthesia
Comparison
Ephedrine administered to correct reductions… vs Phenylephrine administered to correct reductions…
Design
RCT, randomized manner, double-blinded
Follow-up
Immediately following delivery
Authors
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Supports interchangeable use of either vasopressor for cesarean hypotension; confirms equivalent maternal and fetal ANP responses.
RCT (n=30)
double-blinded
randomized
Does ephedrine compared to phenylephrine differentially affect maternal and fetal atrial natriuretic peptide levels during elective cesarean section?
Ephedrine and phenylephrine have similar effects on maternal and fetal atrial natriuretic peptide levels when used to treat hypotension during spinal anesthesia for cesarean section.
Pierce et al. (1994) conducted an RCT in elective cesarean section (n=30). Ephedrine vs. Phenylephrine was evaluated on fetal and maternal plasma atrial natriuretic peptide (ANP) concentrations. Ephedrine and phenylephrine administered for blood pressure correction during elective cesarean section produced no significant differences in maternal or fetal atrial natriuretic peptide levels.
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