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October 1, 1995Acta Anaesthesiologica Scandinavica

Phenylephrine in treating maternal hypotension due to spinal anaesthesia for caesarean delivery: effects on neonatal catecholamine concentrations, acid base status and Apgar scores

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Why the study?

Does phenylephrine compared to ephedrine reduce neonatal and maternal catecholamine concentrations in parturients with hypotension during spinal anaesthesia for caesarean delivery?

Population

40 healthy non-labouring parturients undergoing caesarean delivery with spinal anaesthesia who experienced a…

Comparison

Phenylephrine 40 micrograms intravenous bolus… vs Ephedrine 5 mg intravenous bolus injections to…

Design

RCT, randomly assigned

Follow-up

at the time of delivery

Authors

RLR. F. LaPortaDr.North Shore University HospitalGAG. Richard ArthurHospital of the University of PennsylvaniaSDSanjay DattaFred Hutch Cancer Center

Discussion

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Implication

Phenylephrine may be preferred over ephedrine for caesarean hypotension; reinforces its first-line status by demonstrating lower neonatal catecholamine exposure in RCT data.

Structured PICO

Does phenylephrine compared to ephedrine reduce neonatal and maternal catecholamine concentrations in parturients with hypotension during spinal anaesthesia for caesarean delivery?

P
Population
40 healthy non-labouring parturients undergoing caesarean delivery with spinal anaesthesia who experienced a drop in maternal blood pressure
I
Intervention
Phenylephrine 40 micrograms intravenous bolus injections to maintain maternal systolic blood pressure above 100 mmHg
C
Comparator
Ephedrine 5 mg intravenous bolus injections to maintain maternal systolic blood pressure above 100 mmHg
O
Outcome
Maternal and neonatal catecholamine concentrations (maternal vein, umbilical vein, and umbilical artery) at the time of deliverysurrogate

Phenylephrine is as safe and effective as ephedrine for treating maternal hypotension during caesarean delivery, but is associated with significantly lower noradrenaline concentrations in both mother and neonate and better fetal acid-base status.

Cite This Study

LaPortaDr. et al. (1995) studied this question.

synapsesocial.com/papers/6a9807a0bf4318b353fa934fhttps://doi.org/10.1111/j.1399-6576.1995.tb04195.x
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PLASMA PRESSORS IN THE NORMAL AND STRESSED NEWBORN INFANT1972 · 27 citations
  2. 2Effects of Equipotent Ephedrine, Metaraminol, Mephentermine, and Methoxamine on Uterine Blood Flow in the Pregnant Ewe1974 · 259 citations