Key result
Phenylephrine 50 μg boluses resulted in similar umbilical artery pH compared to ephedrine 4 mg (7.26 vs 7.25; p=0.86) for treating post-spinal hypotension in pre-eclamptic women.
Why the study?
Does phenylephrine compared to ephedrine improve umbilical artery pH in pre-eclamptic women with hypotension during caesarean section?
Population
80 pre-eclamptic women with a singleton pregnancy undergoing caesarean section with spinal anaesthesia who…
Comparison
Phenylephrine 50 μg intravenous boluses vs Ephedrine 4 mg intravenous boluses
Design
RCT, randomly allocated, double-blind
Authors
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Either agent is appropriate for post-spinal hypotension in pre-eclamptic caesarean delivery; confirms equivalence in this population.
RCT (n=80)
Double-blind
Randomly allocated
Does phenylephrine compared to ephedrine improve umbilical artery pH in pre-eclamptic women with hypotension during caesarean section?
Absolute Event Rate: 7.26% vs 7.25%
p-value: p=0.86
Phenylephrine and ephedrine are equally effective and safe for treating post-spinal hypotension in pre-eclamptic women undergoing caesarean section.
Mohta et al. (2018) conducted an RCT in Post-spinal hypotension in pre-eclampsia during caesarean section (n=80). Phenylephrine vs. Ephedrine 4 mg boluses was evaluated on Umbilical artery pH (p=0.86). Phenylephrine 50 μg boluses resulted in similar umbilical artery pH compared to ephedrine 4 mg (7.26 vs 7.25; p=0.86) for treating post-spinal hypotension in pre-eclamptic women.
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