Why the study?
Does ephedrine compared to phenylephrine prevent hypotension and improve fetal outcomes in pregnant women undergoing caesarean section under spinal anaesthesia?
Population
100 patients of ASA Grade I undergoing caesarean section under spinal anaesthesia with a normal singleton…
Comparison
Prophylactic bolus dose of ephedrine 10 mg IV at… vs Prophylactic bolus dose of phenylephrine 100 µg…
Design
RCT, randomly allocated into two groups of 50 each
Follow-up
until end of surgery
Key result
Ephedrine and phenylephrine were equally effective in preventing and treating hypotension during spinal anaesthesia for caesarean section, with no significant differences in fetal outcomes.
Authors
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Bolus phenylephrine and ephedrine appear comparable for spinal hypotension in cesarean delivery; leaves open optimal agent selection pending larger trials.
RCT (n=100)
Randomly allocated
No
Does ephedrine compared to phenylephrine prevent hypotension and improve fetal outcomes in pregnant women undergoing caesarean section under spinal anaesthesia?
p-value: p=not significant
Ephedrine and phenylephrine are equally effective for managing hypotension during spinal anesthesia for cesarean section, with comparable neonatal outcomes.
Haque et al. (2017) conducted an RCT in Hypotension during spinal anaesthesia for caesarean section (n=100). Ephedrine vs. Phenylephrine (100 µg IV prophylactic bolus, 50 µg rescue boluses) was evaluated on Prevention and treatment of hypotension (p=not significant). Ephedrine and phenylephrine were equally effective in preventing and treating hypotension during spinal anaesthesia for caesarean section, with no significant differences in fetal outcomes.
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