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January 1, 2012Journal of Obstetric Anaesthesia and Critical CareOpen Access

Comparison between phenylephrine and ephedrine in preventing hypotension during spinal anesthesia for cesarean section

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Key result

Phenylephrine and ephedrine were equally efficient in managing hypotension during spinal anesthesia for elective cesarean delivery, with no significant difference in neonatal outcomes.

Why the study?

Does phenylephrine compared to ephedrine improve the prevention of hypotension in ASA Grade I patients undergoing elective cesarean section under spinal anesthesia?

Population

100 ASA Grade I patients undergoing elective cesarean section under spinal anesthesia with a normal…

Comparison

Phenylephrine 100 μg IV prophylactic bolus at… vs Ephedrine 10 mg IV prophylactic bolus at the…

Design

RCT, Randomly allocated into two groups of 50 each

Follow-up

Perioperative period (up to delivery and shortly after)

Authors

MBMubasherA BhatINIqra NazirSQSyed Qazi

Discussion

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Overview

Either agent suffices for spinal hypotension in elective cesarean delivery; confirms equivalence without neonatal differences.

Study Design

Type

RCT (n=100)

Randomization

Randomly allocated

Structured PICO

Does phenylephrine compared to ephedrine improve the prevention of hypotension in ASA Grade I patients undergoing elective cesarean section under spinal anesthesia?

P
Population
100 ASA Grade I pregnant women beyond 36 weeks gestation undergoing elective cesarean section under spinal anesthesia.
I
Intervention
Phenylephrine 100 μg IV prophylactic bolus at the time of intrathecal block with rescue boluses of 50 μg
C
Comparator
Ephedrine 10 mg IV prophylactic bolus at the time of intrathecal block with rescue boluses of 5 mg
O
Outcome
Prevention and treatment of hypotension (assessed via hemodynamic variables like blood pressure and heart rate)surrogate

Phenylephrine and ephedrine are equally effective in managing hypotension during spinal anesthesia for elective cesarean delivery, with no significant differences in neonatal outcomes.

Cite This Study

Bhat et al. (2012) conducted an RCT in Hypotension during spinal anesthesia for cesarean section (n=100). Phenylephrine vs. Ephedrine (10 mg IV prophylactic bolus with rescue boluses of 5 mg) was evaluated on Efficacy in preventing and treating hypotension. Phenylephrine and ephedrine were equally efficient in managing hypotension during spinal anesthesia for elective cesarean delivery, with no significant difference in neonatal outcomes.

synapsesocial.com/papers/6a9eceb76fdb0dc73c916388https://doi.org/10.4103/2249-4472.104734
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ephedrine versus Phenylephrine: Prevention of Hypotension during Spinal Anaesthesia for Cesarean Section and Effects on the Fetus2017
  2. 2A Comparative Study of Ephedrine and Phenylephrine in Averting Hypotension during Cesarean Section under Spinal Anesthesia2022
  3. 3Effects of phenylephrine and ephedrine in prevention and treatment of hypotension during spinal anaesthesia for elective cesarean section2022 · 2 citations
  4. 4Comparing Intravenous Phenylephrine and Ephedrine for Hypotension During Spinal Anesthesia for Elective Cesarean Section: A Randomized Double-Blind Clinical Trial2017 · 5 citations
  5. 5Hemodynamic outcomes of phenylephrine versus ephedrine in spinal anesthesia for cesarean section: A prospective randomized study2023