Key result
Phenylephrine significantly differed from ephedrine in hemodynamic parameters (P<0.0001), with ephedrine causing more fetal acidosis and maternal nausea and vomiting (P=0.03).
Why the study?
Does intravenous phenylephrine compared to ephedrine improve hemodynamics and reduce side effects in pregnant females experiencing hypotension during spinal anesthesia for elective cesarean section?
Population
124 pregnant females admitted for elective cesarean section under spinal anesthesia
Comparison
Intravenous phenylephrine bolus administered in… vs Intravenous ephedrine bolus administered in case…
Design
RCT, Block randomization sampling method, Double-blind
Authors
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Phenylephrine may be preferred over ephedrine for spinal hypotension in cesarean delivery; leaves open confirmation in larger trials on neonatal outcomes.
RCT (n=124)
Double-blind
Block randomization
No
Does intravenous phenylephrine compared to ephedrine improve hemodynamics and reduce side effects in pregnant females experiencing hypotension during spinal anesthesia for elective cesarean section?
p-value: p=<0.0001
Phenylephrine (50 mcg) is recommended over ephedrine for managing hypotension during spinal anesthesia for cesarean section due to better fetal acid-base outcomes and fewer maternal side effects.
Vakili et al. (2017) conducted an RCT in Maternal hypotension due to spinal anesthesia for elective cesarean section (n=124). Phenylephrine vs. Ephedrine (5 mg or 10 mg bolus) was evaluated on Hemodynamic parameters (systolic blood pressure, diastolic blood pressure, and pulse rate) (p=<0.0001). Phenylephrine significantly differed from ephedrine in hemodynamic parameters (P<0.0001), with ephedrine causing more fetal acidosis and maternal nausea and vomiting (P=0.03).
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