Key result
Prophylactic infusion of phenylephrine and norepinephrine prevented postspinal hypotension during cesarean section with fewer maternal side effects and less neonatal acidosis compared to ephedrine.
Why the study?
The ideal vasopressor to prevent postspinal hypotension during elective cesarean section while maintaining maternal blood pressure and placental perfusion with minimal adverse effects has been debated.
Does prophylactic infusion of phenylephrine or norepinephrine prevent postspinal hypotension with fewer side effects compared to ephedrine in patients undergoing elective cesarean section under spinal anesthesia?
Comparison
Prophylactic phenylephrine vs norepinephrine vs ephedrine infusions
Design
Randomized controlled double-blind study
Authors
Loading...
May support epinephrine infusion as phenylephrine alternative in cesarean delivery; leaves open optimal agent and dosing in larger trials.
RCT (n=75)
Double-blind
randomly divided
Does prophylactic infusion of phenylephrine or norepinephrine prevent postspinal hypotension with fewer side effects compared to ephedrine in patients undergoing elective cesarean section under spinal anesthesia?
Prophylactic infusion of phenylephrine or norepinephrine is preferable to ephedrine for preventing postspinal hypotension during cesarean section due to a better maternal and fetal side effect profile.
Eskandr et al. (2021) conducted an RCT in postspinal hypotension during elective cesarean section (n=75). Phenylephrine or norepinephrine infusion vs. Ephedrine infusion was evaluated on prevention of postspinal hypotension (changes in mean arterial blood pressure and heart rate). Prophylactic infusion of phenylephrine and norepinephrine prevented postspinal hypotension during cesarean section with fewer maternal side effects and less neonatal acidosis compared to ephedrine.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: