Key result
Phenylephrine alone was more effective in preventing maternal hypotension (13.3% vs 63.3%, p<0.05) and nausea/vomiting than ephedrine alone during spinal anesthesia for cesarean section.
Why the study?
Does phenylephrine or a combination of ephedrine and phenylephrine improve maternal hypotension compared to ephedrine alone in women undergoing spinal anesthesia for cesarean section?
Population
90 women undergoing spinal anesthesia for cesarean section
Comparison
Phenylephrine 33.3g/min infusion with 50g bolus… vs Ephedrine 2 mg/min infusion with 6 mg bolus (n=30)
Design
Other
Authors
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Phenylephrine may be preferred to ephedrine alone for preventing hypotension and nausea in cesarean spinal anesthesia; leaves open optimal combinations in larger trials.
RCT (n=90)
Randomized
No
Does phenylephrine or a combination of ephedrine and phenylephrine improve maternal hypotension compared to ephedrine alone in women undergoing spinal anesthesia for cesarean section?
Absolute Event Rate: 13.3% vs 63.3%
p-value: p=<0.05
Phenylephrine or a combination of phenylephrine and ephedrine may be more effective than ephedrine alone for preventing hypotension during spinal anesthesia for cesarean section.
Jung et al. (2006) conducted an RCT in Spinal anesthesia for cesarean section (n=90). Phenylephrine vs. Ephedrine (1.5 mg/min infusion with 1.5 mg bolus) was evaluated on Incidence of maternal hypotension (p=<0.05). Phenylephrine alone was more effective in preventing maternal hypotension (13.3% vs 63.3%, p<0.05) and nausea/vomiting than ephedrine alone during spinal anesthesia for cesarean section.
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