Key result
Rpp20-Rpp25 heterodimerization regulates their RNA-binding activity, subcellular localization, and expression, which is crucial for their role in RNase MRP/P function.
This basic science study demonstrates that the heterodimerization of Rpp20 and Rpp25 is crucial for their RNA-binding activity, localization, and expression in RNase MRP/P function.
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Should not alter clinical practice; animal data extend RNase MRP/P mechanisms but leave human translation open.
Welting et al. (2006) studied this question. Rpp20-Rpp25 heterodimerization was evaluated on RNA-binding activity, subcellular localization, and expression. Rpp20-Rpp25 heterodimerization regulates their RNA-binding activity, subcellular localization, and expression, which is crucial for their role in RNase MRP/P function.
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