Key result
Risk scores developed for MACCE predicted VTE (AUC 0.651) and VTE predictors predicted MACCE (AUC 0.699) in patients undergoing PCI, supporting overlapping pathophysiology.
Why the study?
Do atherosclerosis risk factors predict both major adverse cardiac and cerebrovascular events and venous thromboembolism in patients with coronary artery disease undergoing percutaneous coronary intervention?
Observational
Yes
Do atherosclerosis risk factors predict both major adverse cardiac and cerebrovascular events and venous thromboembolism in patients with coronary artery disease undergoing percutaneous coronary intervention?
Risk factors for atherosclerosis and venous thromboembolism show significant overlap in predictive performance among patients undergoing PCI, supporting a shared pathophysiology.
May support dual-risk assessment post-PCI; leaves open prospective validation of integrated scores.
Atherosclerosis and venous thromboembolism (VTE) share common risk factors. We set to assess the strength of the association between atherosclerosis risk factors and disease manifestation, and VTE, in patients with coronary artery disease undergoing percutaneous coronary intervention. We pooled data from 6 global randomized controlled trials assessing coronary stenting (ENDEAVOR and SIRIUS programs), developed separate risk scores to predict major adverse cardiac and cerebrovascular events (MACCEs: cardiac death, myocardial infarction, and stroke) and VTE, and compared their performance. The 5-year rates of MACCE and VTE were 10.8% and 2.04%, respectively. Selected predictors for MACCE performed equally well in predicting VTE (area under the receiver-operating characteristic curve [AUC] 0.651 vs 0.672), and selected predictors for VTE performed equally well in predicting MACCE (AUC 0.699 vs 0.620). Ejection fraction and age were associated with both MACCE and VTE. These findings support the concept of overlapping pathophysiology of VTE and atherothrombosis.
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Vardi et al. (2014) conducted an observational in Coronary artery disease undergoing percutaneous coronary intervention. Atherosclerosis risk factors was evaluated on Major adverse cardiac and cerebrovascular events (MACCEs) and VTE. Risk scores developed for MACCE predicted VTE (AUC 0.651) and VTE predictors predicted MACCE (AUC 0.699) in patients undergoing PCI, supporting overlapping pathophysiology.
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