Key result
Glandular kallikrein did not directly activate inactive renin but modified the molecular and kinetic properties of trypsin-activated renin to match those of native active renin.
Population
Inactive renin isolated from normal human plasma
Comparison
Treatment with trypsin and/or glandular kallikrein vs Native form of active renin in plasma
Design
Preclinical
Authors
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Hypothesis-generating in animal models; leaves open kallikrein's role in human inactive renin processing.
Glandular kallikrein participates in the activation process of inactive renin, suggesting that inactive renin in human plasma is a renin precursor.
Hiwada et al. (1983) studied this question. Glandular kallikrein was evaluated on Activation of inactive renin and changes in molecular and kinetic properties. Glandular kallikrein did not directly activate inactive renin but modified the molecular and kinetic properties of trypsin-activated renin to match those of native active renin.
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