Key result
Purified rat urinary kallikrein stimulated active renin release from rat renal cortical slices, an effect abolished by trasylol and amiloride but not by indomethacin or propranolol.
Population
Rat renal cortical slices
Comparison
Purified rat urinary kallikrein superfusion vs Superfusion with kallikrein plus various…
Design
Preclinical
Authors
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Does not inform clinical hypertension care; leaves open direct kallikrein effects on renin release for human mechanistic studies.
Kallikrein directly stimulates active renin release from the kidney through a mechanism independent of kinins, prostaglandins, or beta-adrenergic pathways.
Suzuki et al. (1981) studied this question. Purified rat urinary kallikrein was evaluated on Renin release. Purified rat urinary kallikrein stimulated active renin release from rat renal cortical slices, an effect abolished by trasylol and amiloride but not by indomethacin or propranolol.
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