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June 30, 2009International Journal of Sports Medicine

High cardiorespiratory fitness was associated with a lower risk of carotid atherosclerosis compared to low fitness in men (OR 0.71; 95% CI 0.59-0.85; p<0.001).

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Why the study?

Does higher cardiorespiratory fitness reduce the prevalence of carotid atherosclerosis in middle-aged and elderly men?

Population

9,871 Korean men aged 40-81 years

Comparison

High or moderate cardiorespiratory fitness… vs Low cardiorespiratory fitness

Design

Cross-sectional

Key result

High cardiorespiratory fitness was associated with a lower risk of carotid atherosclerosis compared to low fitness in men (OR 0.71; 95% CI 0.59-0.85; p<0.001).

Authors

CLC D LeeSJSae Young JaeCICarlos Iribarren

Discussion

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Overview

Supports fitness-atherosclerosis association in men; leaves open whether interventions reduce plaque.

Study Design

Type

Cross-Sectional (n=9,871)

Structured PICO

Does higher cardiorespiratory fitness reduce the prevalence of carotid atherosclerosis in middle-aged and elderly men?

P
Population
9,871 Korean men aged 40-81 years assessed for the association between cardiorespiratory fitness and carotid atherosclerosis.
E
Exposure
High (≥60%) or moderate (20-<60%) cardiorespiratory fitness (CRF) measured by maximal treadmill exercise test using the Bruce protocol
C
Comparator
Low cardiorespiratory fitness (<20% based on age-specific VO2peak percentiles)
O
Outcome
Presence of carotid atherosclerosis (defined as intima-media wall thickness >1.2 mm or stenosis >25% of carotid arteries measured by B-mode ultrasonography)surrogate

Main Result

Odds Ratio: 0.71 (95% CI 0.59–0.85)

Absolute Event Rate: 7.7% vs 11.7%

p-value: p=<0.001

Higher cardiorespiratory fitness is independently associated with a lower prevalence of carotid atherosclerosis in middle-aged and older men.

Cite This Study

Lee et al. (2009) conducted a cross-sectional in Carotid atherosclerosis (n=9,871). High cardiorespiratory fitness vs. Low cardiorespiratory fitness was evaluated on Presence of carotid atherosclerosis (intima-media wall thickness >1.2 mm or stenosis >25%) (OR 0.71, 95% CI 0.59-0.85, p=<0.001). High cardiorespiratory fitness was associated with a lower risk of carotid atherosclerosis compared to low fitness in men (OR 0.71; 95% CI 0.59-0.85; p<0.001).

synapsesocial.com/papers/6a92c709eb36ee4226183443https://doi.org/10.1055/s-0029-1224179
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