Key result
Hypoxia-evoked gasps are amplified through a disinhibitory microcircuit within the inspiratory neuron chain and a distributed efference copy mechanism generating coordinated gasp-like discharges.
Why the study?
To test the hypothesis that hypoxia-evoked gasps are amplified via an inspiratory neuron disinhibitory microcircuit and an efference copy mechanism coordinating raphe-pontomedullary respiratory network circuits.
This preclinical study elucidates the brain stem network operations and disinhibitory microcircuits that amplify inspiratory drive during hypoxia-induced gasping.
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Advances mechanistic insight into hypoxic gasping in animals; leaves open translation to human respiratory therapies.
Nuding et al. (2023) studied Hypoxia-evoked gasping (animal model) (n=6). Hypoxia (5% O2 in N2) vs. Air ventilation was evaluated on Neuronal firing rate modulations and short-time scale correlations indicative of functional connectivity. Hypoxia-evoked gasps are amplified through a disinhibitory microcircuit within the inspiratory neuron chain and a distributed efference copy mechanism generating coordinated gasp-like discharges.
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