Key result
Vagotomy and bilateral microinjection of MK-801 in the dorsolateral pons significantly decreased nonlinear variability in the respiratory pattern of anesthetized rats.
Population
Urethane-anesthetized, spontaneously breathing adult rats (n=11)
Comparison
Vagotomy followed by bilateral microinjection of… vs Baseline (vagi intact) and surrogate data sets
Design
Preclinical
Authors
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Vagal and pontine inputs shape respiratory variability in rats; leaves open translation to human control or disease.
Both vagal and dorsolateral pontine influences contribute to nonlinear respiratory pattern variability, providing insight into respiratory dynamics.
Dhingra et al. (2011) studied Urethane-anesthetized, spontaneously breathing adult rats (n=11). Vagotomy and bilateral microinjection of MK-801 vs. Vagi intact (baseline) was evaluated on Nonlinear pattern variability in the respiratory cycle. Vagotomy and bilateral microinjection of MK-801 in the dorsolateral pons significantly decreased nonlinear variability in the respiratory pattern of anesthetized rats.
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