Therapeutic options in the management of chronic heart failure. Is there a drug of first choice?
Key result
Novel pharmacological approaches for chronic heart failure developed between 1978 and 1988 produced hemodynamic benefits in some patients, expanding options beyond digitalis and diuretics.
Design
Review
Authors
Discussion
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Implication
Questions single first-choice drug concept in chronic HF; leaves open optimal individualized sequencing today.
PICO
P
Population
chronic heart failure
I
Intervention / Comparator
Novel pharmacological approaches vs Conventional agents (digitalis and diuretics)
A historical review of the evolution of pharmacological therapies for chronic heart failure, questioning the concept of a single first-choice drug.
Cite This Study
Milton Packer (1989) conducted a review in chronic heart failure. Novel pharmacological approaches vs. Conventional agents (digitalis and diuretics) was evaluated. Novel pharmacological approaches for chronic heart failure developed between 1978 and 1988 produced hemodynamic benefits in some patients, expanding options beyond digitalis and diuretics.