'Naturally occurring' anti-D has been studied in four Rh(D) negative males. The presence of this anti-D does not preclude successful deliberate immunization of Rh(D) negative volunteers; 'naturally occurring' anti-D does not provide a marker of non-responders to Rh immunization. 'Naturally occurring' anti-D is not necessarily the result of materno-fetal transfusion at birth.
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Lee et al. (2008) studied this question.
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