Key result
Novel transcripts of the human NAIP gene arise from internal Alu SINE promoters, producing shortened open reading frames that are translated into protein isoforms in various cell lines and tissues.
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No immediate clinical implications; leaves open NAIP isoform roles in cardiovascular apoptosis.
Romanish et al. (2009) studied this question. Alu SINE promoters was evaluated on Identification of novel NAIP transcripts and protein isoforms. Novel transcripts of the human NAIP gene arise from internal Alu SINE promoters, producing shortened open reading frames that are translated into protein isoforms in various cell lines and tissues.
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