Key result
Among children with Kawasaki syndrome in Denmark, 13.3% developed coronary artery abnormalities, with delayed intravenous immunoglobulin, young age, and male sex as significant risk factors.
Why the study?
Does early treatment with intravenous immunoglobulin (before the 10th day of illness) prevent coronary artery abnormalities in children with Kawasaki syndrome?
Population
284 children <15 years of age with Kawasaki syndrome or atypical Kawasaki syndrome in Denmark, 70.4% <5…
Comparison
Intravenous immunoglobulin treatment… vs Not receiving IVIG before the 10th day of illness
Design
Cohort
Authors
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Supports prompt IVIG in Kawasaki syndrome to lower coronary abnormality risk; extends observational data but leaves open prospective validation.
Observational (n=284)
Yes
Does early treatment with intravenous immunoglobulin (before the 10th day of illness) prevent coronary artery abnormalities in children with Kawasaki syndrome?
More than 10% of children with Kawasaki syndrome in Denmark develop coronary artery abnormalities, highlighting the need for early diagnosis and IVIG treatment before the 10th day of illness.
Patel et al. (2012) conducted an observational in Kawasaki syndrome (n=284). Delayed intravenous immunoglobulin, young age, and male sex vs. Early treatment, older age, and female sex was evaluated on Coronary artery abnormalities. Among children with Kawasaki syndrome in Denmark, 13.3% developed coronary artery abnormalities, with delayed intravenous immunoglobulin, young age, and male sex as significant risk factors.
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