Highly Regio‐ and Stereoselective Nickel‐Catalyzed Addition of Dialkyl Phosphites to Ynamides: an Efficient Synthesis of β‐Aminovinylphosphonates

A highly regio‐ and stereoselective, nickel(II)‐catalyzed procedure for the hydrophosphonylation of ynamides has been developed. This protocol provides a straightforward and efficient entry to a series of β‐aminovinylphosphonates that can easily be prepared in good yields from a wide range of ynamides and dialkyl phosphites as well as useful insights into the reactivity of ynamides under nickel catalysis.